England dismissed Pakistan for 328 on Monday to win the second Test by 26 runs in Multan, taking an unbeatable 2-0 lead in the three-match series.
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Pakistan, who resumed the fourth day on 198-4, looked set for victory at one point but fast bowler Mark Wood led England's fightback by removing Mohammad Nawaz for 45 and Saud Shakeel for 94.
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Ollie Robinson dismissed the last batter, Mohammad Ali, for nought some 50 minutes after lunch to spark celebrations among the England players.
Wood finished with 4-65.
England, on their first Test tour of Pakistan for 17 years, won the first Test by 74 runs in Rawalpindi.
The third and final Test begins in Karachi on Saturday.
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Scores: England 281 and 275; Pakistan 202 and 328