Recently-appointed South African white-ball captain Temba Bavuma has been ruled out of the Twenty20 international series against Pakistan, which starts on Saturday, because of a hamstring injury.
It is a further blow to South Africa, who are already missing five leading players because of Indian Premier League commitments.
Wicketkeeper-batsman Heinrich Klaasen will take over as captain for the four-match series which gets under way at the Wanderers Stadium in Johannesburg.
Among the South African absentees not involved in the IPL are opening batsman Reeza Hendricks and all-rounder Dwayne Pretorius, while batsman Rassie van der Dussen is still recovering from a quad muscle injury.
Hendricks has left the squad for the birth of his first child, while Pretorius has not fully recovered from a broken rib.
Fast bowler Lungi Ngidi and leg-spinner Imran Tahir will be taking the field in the IPL for Chennai Super Kings as the first innings in Johannesburg draws to a close, while fast bowlers Kagiso Rabada and Anrich Nortje are contracted to Delhi. David Miller will be playing for Rajasthan Royals.