Chasing the victory target of 213 set by Afghanistan, the home side was dismissed for 149 after 44.4 overs. The second game is on Sunday at the same venue.
Rashid Khan, who was declared Player of the Match award tdedicated it o the victims of the recent Kabul bomb blast.
"We're trying our best to bring back smiles and happiness in whatever way we can," he said.
Check Brief scorecard below:
Afghanistan - 212/6 in 50 Overs (J Ahmadi - 81, G Naib - 41*, A Nurse - 2/34)
West Indies - 149/10 in 44.4 Overs (S Hope - 35, A Joseph - 27, R Khan - 7/18, D Zadran - 2/25)