Chasing the victory target of 213 set by Afghanistan, the home side was dismissed for 149 after 44.4 overs. The second game is on Sunday at the same venue.
Rashid Khan, who was declared Player of the Match award tdedicated it o the victims of the recent Kabul bomb blast.
"We're trying our best to bring back smiles and happiness in whatever way we can," he said.
Check Brief scorecard below:
Afghanistan - 212/6 in 50 Overs (J Ahmadi - 81, G Naib - 41*, A Nurse - 2/34)
West Indies - 149/10 in 44.4 Overs (S Hope - 35, A Joseph - 27, R Khan - 7/18, D Zadran - 2/25)
Rain washes out opening ODI between India and West Indies
India aiming for No.2 Position in ICC Rankings
1st ODI (Preview) - India vs West Indies
West Indies announces squad for upcoming India Series
West Indies beat Afghanistan in 2nd ODI to level the series
Rashid Khan stars as Afghanistan thrash West Indies
Samuels steers West Indies to 7 wicket victory over Afghanistan
West Indies beat Afghanistan by 29 runs in 2nd T20I
Pakistan register first series win in West Indies
Pakistan - 169/2 at stumps on Day 1 of third test